Product Description: N-acetyltransferase, GNAT family, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.1.- (Transferring groups other than amino-acyl groups.);2.3.1.1 (Amino-acid N-acetyltransferase);2.3.1.48 (Histone acetyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Function | GO:1990883 | rRNA cytidine N-acetyltransferase activity |
| Function | GO:0000049 | tRNA binding |
| Process | GO:1904812 | rRNA acetylation involved in maturation of SSU-rRNA |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.87 | 0.60 |
| Trophozoite | expressed | 0.55 | 0.70 |
| Schizont | not expressed | 0.11 | 0.94 |
| Gametocyte | possibly expressed | 0.56 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1020700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.995 | MFS: -1.441 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJJ5
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=5.54) with 6JWQ (Global RMSD=13.23)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.- | Ex: [myelin-proteolipid] O-palmitoyltransferase | CoAKClArgATPADPEDTAMgCl2CaCl2MnCl2AgNO3CoCl2FeSO4... |
| 2.3.1.1 | amino-acid N-acetyltransferase | CoAKClArgEDTAMgCl2CaCl2MnCl2AgNO3CoCl2FeSO4FeCl3BaCl2... |
| 2.3.1.48 | histone acetyltransferase | CoADNARNABF1EDTAMB-3LTK14PU139A-485TTK21CPTH2CPTH6... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101162
Most Similar Human Ortholog: E9PJN6
TM-align score: 0.85 | RMSD: 2.25
Seq Identity: 0.47 | Length: 138 / 1269
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135372 | N-acetyltransferase 10 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 48 | 27 | 68 |
| disruptive | 34 | 105 | 65 | 168 |
| missense | 15 | 80 | 50 | 134 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 84 | 44 | 89 |
| disruptive | 56 | 250 | 121 | 283 |
| missense | 24 | 183 | 95 | 179 |
PlasmoDB Total SNPs: 283
Non-coding: 122 | Synonymous: 119 | Nonsynonymous: 42 | Stop Codon: 0
Protein Length: 1269 | Molecular Weight (kDa): 149.482
UniProt ID(s): Q8IJJ5
PDB ID(s): None
Isoelectric Point: 8.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000182 | GNAT domain |
| InterPro | IPR007807 | Helicase domain |
| InterPro | IPR013562 | tRNA(Met) cytidine acetyltransferase TmcA, N-terminal |
| InterPro | IPR016181 | Acyl-CoA N-acyltransferase |
| InterPro | IPR027992 | Possible tRNA binding domain |
| InterPro | IPR032672 | TmcA/NAT10/Kre33 |
| InterPro | IPR033688 | RNA cytidine acetyltransferase NAT10 |
| PFam | PF05127 | Helicase domain |
| PFam | PF08351 | tRNA(Met) cytidine acetyltransferase TmcA, N-terminal |
| PFam | PF13718 | GNAT domain |
| PFam | PF13725 | Possible tRNA binding domain |
| Superfamily | SSF55729 | Acyl-CoA N-acyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |