About Gene List

PF3D7_1021000

Genome location: Pf3D7_10_v3:848,471..850,485(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.10 0.95
Trophozoite expressed 0.47 0.72
Schizont expressed 0.21 0.87
Gametocyte expressed 0.25 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1021000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.994 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0505200)

  • Relative Growth Rate: 0.06 ± 0.05
  • Confidence: 7.56

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJJ3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139436

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 19 4 25
disruptive 2 10 6 30
missense 2 10 5 28

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 36 11 16
disruptive 3 33 23 68
missense 2 26 20 44

PlasmoDB Total SNPs: 97

Non-coding: 91 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 353 | Molecular Weight (kDa): 42.698

UniProt ID(s): Q8IJJ3

PDB ID(s): None

Isoelectric Point: 9.17

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895