About Gene List

PF3D7_1021100

Genome location: Pf3D7_10_v3:850,616..856,824(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.52 0.75
Trophozoite expressed 0.43 0.74
Schizont expressed 0.27 0.82
Gametocyte possibly expressed 0.32 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1021100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.281 | #Insertions: 11

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0505300)

  • Relative Growth Rate: 0.66 ± 0.19
  • Confidence: 4.70

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0505300)

Modification: Disrupted | RMgm-1957

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJJ2

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.63) with 6JWQ (Global RMSD=17.67)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532849

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 63 35 84
disruptive 95 215 105 287
missense 54 177 92 225

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 25 111 75 105
disruptive 151 440 219 523
missense 87 326 162 334

PlasmoDB Total SNPs: 179

Non-coding: 29 | Synonymous: 77 | Nonsynonymous: 73 | Stop Codon: 0

Protein Information

Protein Length: 1761 | Molecular Weight (kDa): 210.361

UniProt ID(s): Q8IJJ2

PDB ID(s): None

Isoelectric Point: 6.47

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104