PF3D7_1021200

Genome location: Pf3D7_10_v3:857,492..859,989(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	not expressed	0.68	0.62
Schizont	not expressed	0.47	0.72
Gametocyte	not expressed	1.37	0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1021200

Resistome Missense Mutations: H144N

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.161 | MFS: -2.713 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0505400)

Relative Growth Rate: 0.02 ± 0.03
Confidence: 8.40

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJJ1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533017

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	32	22	36
disruptive	20	66	44	111
missense	13	55	33	90

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	66	20	30
disruptive	38	190	88	237
missense	24	140	60	111

PlasmoDB Total SNPs: 133

Non-coding: 72 | Synonymous: 46 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 689 | Molecular Weight (kDa): 82.849

UniProt ID(s): Q8IJJ1

PDB ID(s): None

Isoelectric Point: 6.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104