PF3D7_1021400

Genome location: Pf3D7_10_v3:863,425..867,311(+)

Genome classification: Core

Function and Localization

Product Description: endomembrane protein 70, putative

SignalP Peptide: MIIEHVLCSFILFVCYIIKYADA

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane
Process	GO:0072657	protein localization to membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.05	0.97
Trophozoite	expressed	0.11	0.93
Schizont	expressed	0.05	0.96
Gametocyte	expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1021400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.168 | MFS: -2.866 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZZU2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100462

Most Similar Human Ortholog: Q92544

TM-align score: 0.91 | RMSD: 2.75

Seq Identity: 0.33 | Length: 610 / 619

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000101337	transmembrane 9 superfamily member 4
ENSG00000125304	transmembrane 9 superfamily member 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	32	21	45
disruptive	2	15	10	37
missense	2	15	10	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	79	26	45
disruptive	5	43	32	96
missense	4	35	26	71

PlasmoDB Total SNPs: 238

Non-coding: 207 | Synonymous: 27 | Nonsynonymous: 3 | Stop Codon: 1

Protein Information

Protein Length: 619 | Molecular Weight (kDa): 72.534

UniProt ID(s): A0A143ZZU2

PDB ID(s): None

Isoelectric Point: 9.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004240	Nonaspanin (TM9SF)
PFam	PF02990	Nonaspanin (TM9SF)
Superfamily	N/A	N/A