Product Description: deoxyribose-phosphate aldolase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 4.1.2.4 (Deoxyribose-phosphate aldolase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005622 | intracellular |
| Function | GO:0004139 | deoxyribose-phosphate aldolase activity |
| Process | GO:0016052 | carbohydrate catabolic process |
| Process | GO:0009264 | deoxyribonucleotide catabolic process |
| Process | GO:0006098 | pentose-phosphate shunt |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.13 | 0.93 |
| Trophozoite | expressed | 0.39 | 0.76 |
| Schizont | expressed | 0.05 | 0.97 |
| Gametocyte | expressed | 0.64 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1021600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: -0.96 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_0506900)
Modification: Tagged | RMgm-1553
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJI7
"Best" AlphaFill ligand hit: PGO (s-1,2-propanediol, Local RMSD=0.07) with 3R12 (Global RMSD=3.25)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 4.1.2.4 | deoxyribose-phosphate aldolase | NaBH4OctanolacroleinacetaldehydehydroxylaminecrotonaldehydepropionaldehydeChloral hydrateD-glyceraldehydeChloroacetaldehydep-hydroxymercuribenzoate |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102064
Most Similar Human Ortholog: E9PMH9
TM-align score: 0.91 | RMSD: 1.82
Seq Identity: 0.31 | Length: 161 / 263
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000023697 | deoxyribose-phosphate aldolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 137
Non-coding: 129 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 263 | Molecular Weight (kDa): 28.98
UniProt ID(s): Q8IJI7
PDB ID(s): None
Isoelectric Point: 7.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002915 | DeoC/FbaB/LacD aldolase |
| InterPro | IPR011343 | Deoxyribose-phosphate aldolase |
| InterPro | IPR028581 | Deoxyribose-phosphate aldolase type I |
| PFam | PF01791 | DeoC/FbaB/LacD aldolase |
| Superfamily | SSF51569 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27503796 | Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. | Siau A, Huang X, ..., Preiser PR | 10.1038/srep31055 |