PF3D7_1021700

Genome location: Pf3D7_10_v3:872,294..895,304(-)

Genome classification: Core

Function and Localization

Product Description: VPS13 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.95	0.64
Trophozoite	expressed	1.70	0.28
Schizont	expressed	2.75	0.25
Gametocyte	possibly expressed	2.17	0.17

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1021700

Resistome Missense Mutations: D1212N, P3925S, T5566P

Resistome Compounds with Missense Mutations: BCH070, MMV019066, MMV019313, MMV973707, Suloctidil

Resistome # Samples with Disruptive Mutations: 11 (11 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.973 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0505900)

Modification: Disrupted | RMgm-1960

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179341

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	59	242	128	303
disruptive	306	736	397	1004
missense	146	517	293	749

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	86	468	225	423
disruptive	575	1609	740	1664
missense	244	1044	521	1109

PlasmoDB Total SNPs: 961

Non-coding: 167 | Synonymous: 436 | Nonsynonymous: 358 | Stop Codon: 0

Protein Information

Protein Length: 6934 | Molecular Weight (kDa): 830.195

UniProt ID(s): Q8IJI6

PDB ID(s): None

Isoelectric Point: 9.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026854	Vacuolar protein sorting-associated protein 13-like, N-terminal domain
PFam	PF12624	Vacuolar protein sorting-associated protein 13-like, N-terminal domain
Superfamily	N/A	N/A