About Gene List

PF3D7_1021800 (SEA1)

Genome location: Pf3D7_10_v3:895,818..903,665(-)

Genome classification: Core

Function and Localization

Product Description: schizont egress antigen-1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0000775 chromosome, centromeric region
Component GO:0033644 host cell membrane
Component GO:0005634 nucleus
Component GO:0020005 symbiont-containing vacuole membrane
Process GO:0035891 exit from host cell
Process GO:0098813 nuclear chromosome segregation
Process GO:0020014 schizogony

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.26 0.88
Trophozoite expressed 1.35 0.40
Schizont expressed 2.87 0.11
Gametocyte possibly expressed 1.53 0.31

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1021800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.424 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXM2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_192919

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 75 39 78
disruptive 70 233 121 305
missense 39 184 96 253

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 22 133 48 98
disruptive 130 447 232 424
missense 75 337 185 314

PlasmoDB Total SNPs: 482

Non-coding: 160 | Synonymous: 173 | Nonsynonymous: 149 | Stop Codon: 0

Protein Information

Protein Length: 2074 | Molecular Weight (kDa): 244.902

UniProt ID(s): A0A143ZXM2

PDB ID(s): None

Isoelectric Point: 4.71

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011051 RmlC-like cupin domain superfamily
PFam N/A N/A
Superfamily SSF51182 RmlC-like cupin domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
24855263 Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malariainfection. Raj DK, Nixon CP, ..., Kurtis JD 10.1126/science.1254417
33688001 Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony Perrin AJ, Bisson C, ..., Blackman MJ 10.1128/mBio.03377-20