Product Description: PHAX domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.42 | 0.82 |
| Trophozoite | expressed | 2.14 | 0.18 |
| Schizont | expressed | 1.48 | 0.40 |
| Gametocyte | expressed | 1.79 | 0.24 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1021900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.385 | MFS: -2.603 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1020300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJI4
"Best" AlphaFill ligand hit: TAR (d(-)-tartaric acid, Local RMSD=0.28) with 6MOJ (Global RMSD=3.00)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100012
Most Similar Human Ortholog: C9JY51
TM-align score: 0.92 | RMSD: 1.00
Seq Identity: 0.37 | Length: 76 / 2290
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000029534 | ankyrin 1 |
| ENSG00000065413 | ankyrin repeat domain 44 |
| ENSG00000139645 | ankyrin repeat domain 52 |
| ENSG00000145362 | ankyrin 2 |
| ENSG00000151150 | ankyrin 3 |
| ENSG00000151458 | ankyrin repeat domain 50 |
| ENSG00000206560 | ankyrin repeat domain 28 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 96 | 39 | 120 |
| disruptive | 111 | 332 | 148 | 410 |
| missense | 46 | 212 | 118 | 296 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 39 | 194 | 76 | 145 |
| disruptive | 208 | 725 | 293 | 690 |
| missense | 71 | 481 | 209 | 409 |
PlasmoDB Total SNPs: 561
Non-coding: 168 | Synonymous: 239 | Nonsynonymous: 154 | Stop Codon: 0
Protein Length: 2290 | Molecular Weight (kDa): 267.386
PDB ID(s): None
Isoelectric Point: 9.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002110 | Ankyrin repeat |
| InterPro | IPR019385 | Phosphorylated adapter RNA export protein, RNA-binding domain |
| InterPro | IPR020683 | Ankyrin repeat-containing domain |
| InterPro | IPR036770 | Ankyrin repeat-containing domain superfamily |
| PFam | PF10258 | Phosphorylated adapter RNA export protein, RNA-binding domain |
| PFam | PF12796 | Ankyrin repeat-containing domain |
| Superfamily | SSF48403 | Ankyrin repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |