Product Description: RNA-binding protein UIS12, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:1990904 | ribonucleoprotein complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.45 | 0.79 |
| Trophozoite | expressed | 0.98 | 0.49 |
| Schizont | expressed | 0.22 | 0.87 |
| Gametocyte | not expressed | 0.69 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1022000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.001 | #Insertions: 7
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0506200)
Modification: Disrupted | RMgm-4956
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJI3
"Best" AlphaFill ligand hit: DW0 (1,1'-propane-1,3-diylbis(3,7-dimethyl-3,7-dihydro-1h-purine-2,6-dione), Local RMSD=0.05) with 8OSE (Global RMSD=18.73)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 62 | 25 | 72 |
| disruptive | 29 | 135 | 72 | 198 |
| missense | 19 | 101 | 61 | 153 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 108 | 53 | 96 |
| disruptive | 56 | 322 | 195 | 423 |
| missense | 33 | 231 | 150 | 243 |
PlasmoDB Total SNPs: 344
Non-coding: 206 | Synonymous: 91 | Nonsynonymous: 47 | Stop Codon: 0
Protein Length: 1426 | Molecular Weight (kDa): 167.243
UniProt ID(s): Q8IJI3
PDB ID(s): None
Isoelectric Point: 9.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |