Product Description: methyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.43 (Transferred entry: 2.1.1.354)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.46 | 0.78 |
| Trophozoite | expressed | 0.16 | 0.90 |
| Schizont | expressed | 0.05 | 0.97 |
| Gametocyte | possibly expressed | 0.13 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1022100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.578 | #Insertions: 3
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0506300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0506300)
Modification: Disrupted | RMgm-1962
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3D3
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.1.1.43 | histone-lysine N-methyltransferase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102864
Most Similar Human Ortholog: O95568
TM-align score: 0.76 | RMSD: 2.32
Seq Identity: 0.30 | Length: 213 / 259
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000171806 | methyltransferase like 18 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 8 | 2 | 12 |
| disruptive | 1 | 9 | 5 | 29 |
| missense | 1 | 9 | 5 | 23 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 17 | 12 | 16 |
| disruptive | 6 | 37 | 23 | 54 |
| missense | 2 | 30 | 20 | 37 |
PlasmoDB Total SNPs: 25
Non-coding: 21 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 259 | Molecular Weight (kDa): 30.479
UniProt ID(s): C6S3D3
PDB ID(s): None
Isoelectric Point: 9.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019410 | Lysine methyltransferase |
| InterPro | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase |
| PFam | PF10294 | Lysine methyltransferase |
| Superfamily | SSF53335 | S-adenosyl-L-methionine-dependent methyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |