PF3D7_1022200

Genome location: Pf3D7_10_v3:926,542..929,405(-)

Genome classification: Core

Function and Localization

Product Description: folate-biopterin transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 12

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.08	0.96
Trophozoite	expressed	0.45	0.72
Schizont	expressed	0.12	0.92
Gametocyte	possibly expressed	0.21	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1022200

Resistome Missense Mutations: Q539E

Resistome Compounds with Missense Mutations: MMV006901

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.154 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJI2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532912

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	28	13	34
disruptive	11	37	23	76
missense	11	36	19	69

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	54	22	40
disruptive	20	100	55	159
missense	14	78	43	111

PlasmoDB Total SNPs: 111

Non-coding: 61 | Synonymous: 40 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 629 | Molecular Weight (kDa): 74.845

UniProt ID(s): Q8IJI2

PDB ID(s): None

Isoelectric Point: 9.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036259	MFS transporter superfamily
InterPro	IPR039309	Biopterin transporter family
PFam	N/A	N/A
Superfamily	SSF103473	MFS transporter superfamily

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097