Product Description: ZIP domain-containing protein, putative
SignalP Peptide: MWLSTFLALLIFVEC
# Transmembrane Domains: 7
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016020 | membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0005381 | iron ion transmembrane transporter activity |
| Function | GO:0046873 | metal ion transmembrane transporter activity |
| Function | GO:0005385 | zinc ion transmembrane transporter activity |
| Process | GO:0071577 | zinc ion transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.03 | 0.98 |
| Schizont | possibly expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1022300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.502 | #Insertions: 3
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0506500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0506500)
Modification: Disrupted | RMgm-1963
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJI1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 11 | 6 | 14 |
| disruptive | 1 | 9 | 10 | 23 |
| missense | 0 | 7 | 8 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 19 | 8 | 20 |
| disruptive | 3 | 29 | 23 | 44 |
| missense | 1 | 14 | 17 | 29 |
PlasmoDB Total SNPs: 101
Non-coding: 82 | Synonymous: 18 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 325 | Molecular Weight (kDa): 37.165
UniProt ID(s): Q8IJI1
PDB ID(s): None
Isoelectric Point: 6.23
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003689 | Zinc/iron permease |
| PFam | PF02535 | Zinc/iron permease |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25257508 | ZIPCO, a putative metal ion transporter, is crucial for Plasmodium liver-stagedevelopment. | Sahu T, Boisson B, ..., Baldacci P | 10.15252/emmm.201403868 |