Product Description: serine/arginine-rich splicing factor 4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000375 | RNA splicing, via transesterification reactions |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.01 | 0.55 |
| Trophozoite | expressed | 1.32 | 0.37 |
| Schizont | expressed | 0.33 | 0.80 |
| Gametocyte | expressed | 0.47 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1022400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.558 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0506600)
Modification: Disrupted | RMgm-5088
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJI0
"Best" AlphaFill ligand hit: ADE (adenine, Local RMSD=2.29) with 3LQV (Global RMSD=4.60)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102665
Most Similar Human Ortholog: J3QQV5
TM-align score: 0.71 | RMSD: 1.34
Seq Identity: 0.40 | Length: 52 / 538
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000111786 | serine and arginine rich splicing factor 9 |
| ENSG00000136450 | serine and arginine rich splicing factor 1 |
| ENSG00000266086 | novel transcript |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 15 | 16 | 25 |
| disruptive | 9 | 60 | 30 | 86 |
| missense | 8 | 56 | 28 | 80 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 38 | 13 | 34 |
| disruptive | 20 | 106 | 50 | 108 |
| missense | 17 | 93 | 48 | 86 |
PlasmoDB Total SNPs: 86
Non-coding: 60 | Synonymous: 16 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 538 | Molecular Weight (kDa): 62.117
UniProt ID(s): Q8IJI0
PDB ID(s): None
Isoelectric Point: 10.56
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25188378 | Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparumimpairs blood stage replication and malaria transmission. | Kern S, Agarwal S, ..., Pradel G | 10.1371/journal.pone.0105732 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |