Genome location: Pf3D7_10_v3:948,397..952,528(+)
Genome classification: Core
Product Description: kelch protein K10
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0005515 | protein binding |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 1.39 | 0.41 |
| Trophozoite | possibly expressed | 0.70 | 0.63 |
| Schizont | possibly expressed | 0.18 | 0.90 |
| Gametocyte | not expressed | 0.83 | 0.56 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1022600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.928 | #Insertions: 4
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJH9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103804
Most Similar Human Ortholog: H3BTB1
TM-align score: 0.74 | RMSD: 1.42
Seq Identity: 0.16 | Length: 38 / 891
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104731 | kelch domain containing 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 30 | 14 | 45 |
| disruptive | 13 | 53 | 48 | 116 |
| missense | 6 | 50 | 41 | 109 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 54 | 32 | 55 |
| disruptive | 27 | 150 | 74 | 151 |
| missense | 10 | 129 | 63 | 124 |
PlasmoDB Total SNPs: 78
Non-coding: 19 | Synonymous: 35 | Nonsynonymous: 23 | Stop Codon: 1
Protein Length: 891 | Molecular Weight (kDa): 105.711
UniProt ID(s): Q8IJH9
PDB ID(s): None
Isoelectric Point: 6.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR015915 | Kelch-type beta propeller |
| InterPro | IPR025183 | Domain of unknown function DUF4110 |
| PFam | PF13418 | Domain of unknown function DUF4110 |
| PFam | PF13422 | |
| PFam | PF13854 | |
| PFam | PF13964 | |
| Superfamily | SSF117281 | Kelch-type beta propeller |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 28454557 | Longitudinal genomic surveillance of Plasmodium falciparum malaria parasitesreveals complex genomic architecture of emerging artemisinin resistance. | Cerqueira GC, Cheeseman IH, ..., Neafsey DE | 10.1186/s13059-017-1204-4 |
| 32098816 | The Plasmodium falciparum Artemisinin Susceptibility-Associated A P-2 Adaptin mu Subunit is Clathrin Independent and Essential for Schizont Maturation | Henrici RC, Edwards RL, ..., Sutherland CJ | 10.1128/mBio.02918-19 |