About Gene List

PF3D7_1022700 (PLSCR)

Genome location: Pf3D7_10_v3:951,189..953,537(-)

Genome classification: Core

Function and Localization

Product Description: phospholipid scramblase

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane
Component GO:0005886 plasma membrane
Function GO:0005509 calcium ion binding
Function GO:0000287 magnesium ion binding
Function GO:0017128 phospholipid scramblase activity
Process GO:0017121 plasma membrane phospholipid scrambling

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite expressed 0.01 1.00
Schizont expressed 0.16 0.89
Gametocyte expressed 0.02 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1022700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.841 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0506900)

  • Relative Growth Rate: 1.01 ± 0.06
  • Confidence: 6.90

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0506900)

Modification: Disrupted | RMgm-1964

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJH8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100156

Most Similar Human Ortholog: C9J0H3

TM-align score: 0.79 | RMSD: 2.07

Seq Identity: 0.19 | Length: 151 / 275

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000188313 phospholipid scramblase 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 107

Non-coding: 97 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 275 | Molecular Weight (kDa): 33.019

UniProt ID(s): Q8IJH8

PDB ID(s): None

Isoelectric Point: 7.81

Protein Domain Annotations:

Source Family ID Description
InterPro IPR005552 Scramblase
PFam PF03803 Scramblase
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
33974939 Identification and characterisation of a phospholipid scramblase in the malariaparasite Plasmodium falciparum. Haase S, Condron M, ..., Baum J 10.1016/j.molbiopara.2021.111374
33569461 Effect and mechanism of phospholipid scramblase 4 (PLSCR4) on lipopolysaccharide(LPS)-induced injury to human pulmonary microvascular endothelial cells Liu X, Wang D, ..., Wang Y 10.21037/atm-20-7983