About Gene List

PF3D7_1022900 (ApiCOX13)

Genome location: Pf3D7_10_v3:958,464..960,482(-)

Genome classification: Core

Function and Localization

Product Description: cytochrome c oxidase subunit ApiCOX13, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005751 mitochondrial respiratory chain complex IV
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite expressed 0.03 0.98
Schizont expressed 0.02 0.99
Gametocyte expressed 0.04 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1022900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.997 | MFS: -2.01 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0507100)

  • Relative Growth Rate: 0.19 ± 0.27
  • Confidence: 4.03

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJH6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104066

Most Similar Human Ortholog: P0C7P0

TM-align score: 0.65 | RMSD: 1.85

Seq Identity: 0.31 | Length: 84 / 118

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000274768 CDGSH iron sulfur domain 3
ENSG00000277972 CDGSH iron sulfur domain 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 102

Non-coding: 101 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 118 | Molecular Weight (kDa): 13.87

UniProt ID(s): Q8IJH6

PDB ID(s): None

Isoelectric Point: 9.41

Protein Domain Annotations:

Source Family ID Description
InterPro IPR018967 Iron sulphur-containing domain, CDGSH-type
PFam PF09360 Iron sulphur-containing domain, CDGSH-type
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30204084 Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase Seidi A, Muellner-Wong LS, ..., van Dooren GG 10.7554/eLife.38131
34155201 Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum. Evers F, Cabrera-Orefice A, ..., Kooij TWA 10.1038/s41467-021-23919-x
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21