About Gene List

PF3D7_1023000

Genome location: Pf3D7_10_v3:960,653..962,723(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.68 0.75
Trophozoite not expressed 0.34 0.79
Schizont expressed 0.69 0.63
Gametocyte possibly expressed 0.52 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1023000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.771 | MFS: -3.115 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0507200)

  • Relative Growth Rate: 1.02 ± 0.06
  • Confidence: 6.88

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0507200)

Modification: Disrupted | RMgm-1967

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJH5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533014

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 10 11 12
disruptive 6 28 13 58
missense 5 25 12 49

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 25 14 30
disruptive 20 97 63 143
missense 10 70 43 81

PlasmoDB Total SNPs: 67

Non-coding: 47 | Synonymous: 13 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 413 | Molecular Weight (kDa): 48.919

UniProt ID(s): Q8IJH5

PDB ID(s): None

Isoelectric Point: 8.94

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
20037583 Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. Hu G, Cabrera A, ..., Bozdech Z 10.1038/nbt.1597