Product Description: HORMA domain protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0016035 | zeta DNA polymerase complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.28 | 0.82 |
| Schizont | not expressed | 0.12 | 0.92 |
| Gametocyte | not expressed | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1023400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.286 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJH1
"Best" AlphaFill ligand hit: CXS (3-cyclohexyl-1-propylsulfonic acid, Local RMSD=0.09) with 6EKJ (Global RMSD=1.08)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104299
Most Similar Human Ortholog: B1AK44
TM-align score: 0.82 | RMSD: 2.77
Seq Identity: 0.20 | Length: 185 / 195
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000116670 | mitotic arrest deficient 2 like 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 8 | 2 | 11 |
| disruptive | 5 | 14 | 5 | 17 |
| missense | 5 | 14 | 4 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 14 | 9 | 15 |
| disruptive | 10 | 26 | 16 | 29 |
| missense | 9 | 22 | 11 | 19 |
PlasmoDB Total SNPs: 66
Non-coding: 59 | Synonymous: 3 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 195 | Molecular Weight (kDa): 23.929
UniProt ID(s): Q8IJH1
PDB ID(s): None
Isoelectric Point: 4.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036570 | HORMA domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF56019 | HORMA domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |