PF3D7_1023600

Genome location: Pf3D7_10_v3:987,358..990,148(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.19	0.87
Schizont	not expressed	0.13	0.91
Gametocyte	possibly expressed	0.82	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1023600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.953 | MFS: -2.687 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0507800)

Relative Growth Rate: 1.01 ± 0.14
Confidence: 5.32

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0507800)

Modification: Disrupted | RMgm-1970

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJG9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104472

Most Similar Human Ortholog: E9PQV5

TM-align score: 0.35 | RMSD: 4.50

Seq Identity: 0.07 | Length: 60 / 512

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000163885	cilia and flagella associated protein 100

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	18	12	31
disruptive	11	31	21	56
missense	9	29	18	48

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	50	9	31
disruptive	29	86	50	112
missense	13	63	33	88

PlasmoDB Total SNPs: 156

Non-coding: 132 | Synonymous: 19 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 512 | Molecular Weight (kDa): 62.067

UniProt ID(s): Q8IJG9

PDB ID(s): None

Isoelectric Point: 9.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A