PF3D7_1023700

Genome location: Pf3D7_10_v3:991,147..993,420(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.01	1.00
Gametocyte	possibly expressed	0.33	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1023700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.49 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0507900)

Relative Growth Rate: 1.02 ± 0.17
Confidence: 4.94

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0507900)

Modification: Disrupted | RMgm-1971

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJG8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532691

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	28	23	42
disruptive	9	55	38	83
missense	9	54	32	74

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	57	29	54
disruptive	26	133	56	160
missense	17	114	45	115

PlasmoDB Total SNPs: 47

Non-coding: 0 | Synonymous: 29 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 757 | Molecular Weight (kDa): 89.748

UniProt ID(s): Q8IJG8

PDB ID(s): None

Isoelectric Point: 8.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A