PF3D7_1023800

Genome location: Pf3D7_10_v3:994,299..997,092(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.25	0.89
Trophozoite	not expressed	0.13	0.93
Schizont	not expressed	0.30	0.85
Gametocyte	not expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1023800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.865 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0508000)

Modification: Disrupted | RMgm-313

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJG7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533457

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	23	17	40
disruptive	48	123	73	132
missense	31	77	52	97

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	59	30	55
disruptive	86	242	93	183
missense	49	154	74	116

PlasmoDB Total SNPs: 170

Non-coding: 59 | Synonymous: 55 | Nonsynonymous: 56 | Stop Codon: 0

Protein Information

Protein Length: 757 | Molecular Weight (kDa): 90.933

UniProt ID(s): Q8IJG7

PDB ID(s): None

Isoelectric Point: 9.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A