Product Description: chromodomain-helicase-DNA-binding protein 1 homolog, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.4.12 (DNA helicase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 3.05 | 0.07 |
| Trophozoite | expressed | 2.99 | 0.05 |
| Schizont | expressed | 3.43 | 0.02 |
| Gametocyte | expressed | 1.96 | 0.22 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1023900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.449 | #Insertions: 2
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0508100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.4.12 | DNA helicase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102222
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 3328
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000153922 | chromodomain helicase DNA binding protein 1 |
| ENSG00000173575 | chromodomain helicase DNA binding protein 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 39 | 148 | 101 | 205 |
| disruptive | 135 | 352 | 190 | 538 |
| missense | 53 | 244 | 142 | 404 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 62 | 334 | 150 | 232 |
| disruptive | 219 | 770 | 387 | 878 |
| missense | 81 | 541 | 282 | 588 |
PlasmoDB Total SNPs: 469
Non-coding: 194 | Synonymous: 175 | Nonsynonymous: 100 | Stop Codon: 0
Protein Length: 3328 | Molecular Weight (kDa): 381.254
UniProt ID(s): Q8IJG6
PDB ID(s): None
Isoelectric Point: 6.24
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000330 | SNF2-related, N-terminal domain |
| InterPro | IPR000953 | Chromo/chromo shadow domain |
| InterPro | IPR001650 | Helicase, C-terminal |
| InterPro | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| InterPro | IPR016197 | Chromo-like domain superfamily |
| InterPro | IPR023780 | Chromo domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00176 | SNF2-related, N-terminal domain |
| PFam | PF00271 | Helicase, C-terminal |
| PFam | PF00385 | Chromo domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF54160 | Chromo-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19765590 | Potential epigenetic regulatory proteins localise to distinct nuclearsub-compartments in Plasmodium falciparum. | Volz J, Carvalho TG, ..., Cowman AF | 10.1016/j.ijpara.2009.09.002 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 29590075 | GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependentgene silencing. | Filarsky M, Fraschka SA, ..., Voss TS | 10.1126/science.aan6042 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 38266035 | A genome-wide comprehensive analysis of nucleosome positioning in yeast | Zeitler L, Andre K, ..., Goldar A | 10.1371/journal.pcbi.1011799 |