About Gene List

PF3D7_1024000

Genome location: Pf3D7_10_v3:1,014,459..1,016,982(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MRKNIILVAYICFIYMRAKCEA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.59 0.74
Trophozoite expressed 0.90 0.52
Schizont expressed 0.33 0.81
Gametocyte not expressed 0.34 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1024000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -2.923 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJG5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533068

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 20 18 28
disruptive 10 53 30 81
missense 5 42 26 67

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 47 19 30
disruptive 24 104 82 157
missense 11 74 67 97

PlasmoDB Total SNPs: 187

Non-coding: 125 | Synonymous: 37 | Nonsynonymous: 24 | Stop Codon: 1

Protein Information

Protein Length: 566 | Molecular Weight (kDa): 66.716

UniProt ID(s): Q8IJG5

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895