About Gene List

PF3D7_1024100

Genome location: Pf3D7_10_v3:1,016,823..1,020,866(-)

Genome classification: Core

Function and Localization

Product Description: ookinete maturation gene OMG1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite possibly expressed 0.17 0.89
Schizont not expressed 0.07 0.95
Gametocyte expressed 0.32 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1024100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -2.57 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0508300)

Modification: Disrupted | RMgm-5202

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJG4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532453

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 21 39 26 54
disruptive 68 131 83 162
missense 40 95 71 130

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 77 38 49
disruptive 118 273 112 224
missense 57 208 89 170

PlasmoDB Total SNPs: 282

Non-coding: 69 | Synonymous: 113 | Nonsynonymous: 99 | Stop Codon: 1

Protein Information

Protein Length: 1104 | Molecular Weight (kDa): 131.54

UniProt ID(s): Q8IJG4

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
35947628 Identification of a novel AP2 transcription factor in zygotes with an essentialrole in Plasmodium ookinete development. Nishi T, Kaneko I, Iwanaga S, Yuda M 10.1371/journal.ppat.1010510