PF3D7_1024200

Genome location: Pf3D7_10_v3:1,020,895..1,022,060(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion
Component	GO:1990904	ribonucleoprotein complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.08	0.95
Schizont	expressed	0.01	0.99
Gametocyte	possibly expressed	0.07	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1024200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.721 | MFS: -2.759 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0508400)

Relative Growth Rate: 0.06 ± 0.04
Confidence: 8.02

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJG3

"Best" AlphaFill ligand hit: ADE (adenine, Local RMSD=4.23) with 3LQV (Global RMSD=7.73)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133884

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	5	11
disruptive	1	10	10	14
missense	1	10	10	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	16	6	13
disruptive	4	25	18	32
missense	3	24	18	23

PlasmoDB Total SNPs: 51

Non-coding: 40 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 160 | Molecular Weight (kDa): 19.447

UniProt ID(s): Q8IJG3

PDB ID(s): None

Isoelectric Point: 9.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR035979	RNA-binding domain superfamily
PFam	PF00076	RNA recognition motif domain
Superfamily	SSF54928	RNA-binding domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21