Genome location: Pf3D7_10_v3:1,022,202..1,023,132(+)
Genome classification: Core
Product Description: ATP synthase-associated protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Process | GO:0015986 | ATP synthesis coupled proton transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.26 | 0.83 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | expressed | 0.26 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1024300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.133 | MFS: -3.265 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJG2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 5 | 4 | 8 |
| disruptive | 1 | 3 | 2 | 4 |
| missense | 0 | 3 | 1 | 3 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 15 | 2 | 7 |
| disruptive | 4 | 8 | 4 | 23 |
| missense | 1 | 5 | 2 | 19 |
PlasmoDB Total SNPs: 65
Non-coding: 62 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 130 | Molecular Weight (kDa): 15.559
UniProt ID(s): Q8IJG2
PDB ID(s): None
Isoelectric Point: 5.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 31390575 | Landscape of the Plasmodium Interactome Reveals Both Conserved andSpecies-Specific Functionality. | Hillier C, Pardo M, ..., Choudhary JS | 10.1016/j.celrep.2019.07.019 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |