PF3D7_1024400

Genome location: Pf3D7_10_v3:1,023,189..1,025,165(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.14	0.92
Schizont	not expressed	0.23	0.86
Gametocyte	possibly expressed	0.69	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1024400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.228 | MFS: -2.758 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJG1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533056

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	23	19	17
disruptive	12	64	39	86
missense	11	60	36	77

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	44	16	27
disruptive	34	143	54	119
missense	23	123	45	85

PlasmoDB Total SNPs: 83

Non-coding: 45 | Synonymous: 21 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 502 | Molecular Weight (kDa): 59.364

UniProt ID(s): Q8IJG1

PDB ID(s): None

Isoelectric Point: 6.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A