PF3D7_1024600

Genome location: Pf3D7_10_v3:1,026,920..1,029,574(-)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.08	0.96
Trophozoite	expressed	0.44	0.74
Schizont	expressed	0.09	0.95
Gametocyte	possibly expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1024600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.262 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJF8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156402

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	13	10	25
disruptive	4	22	18	44
missense	3	22	18	41

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	28	22	34
disruptive	8	68	44	78
missense	5	52	39	62

PlasmoDB Total SNPs: 124

Non-coding: 88 | Synonymous: 30 | Nonsynonymous: 5 | Stop Codon: 1

Protein Information

Protein Length: 433 | Molecular Weight (kDa): 52.206

UniProt ID(s): Q8IJF8

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011335	Restriction endonuclease type II-like
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	SSF52980	Restriction endonuclease type II-like

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094