Genome location: Pf3D7_10_v3:1,032,432..1,040,157(+)
Genome classification: Core
Product Description: exported protein 3
SignalP Peptide: MQIPTKFLVFFNLVILFVFLNFERVEL
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0020003 | symbiont-containing vacuole |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Function | GO:0005515 | protein binding |
| Function | GO:0044877 | protein-containing complex binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.99 | 0.10 |
| Trophozoite | expressed | 2.24 | 0.13 |
| Schizont | expressed | 1.09 | 0.48 |
| Gametocyte | expressed | 3.05 | 0.05 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1024800
Resistome Missense Mutations: D279E, D282G, H867N, D868N, D869N, D872H
Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609, MMV084978
Resistome # Samples with Disruptive Mutations: 4 (3 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.161 | #Insertions: 7
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0509000)
Modification: Tagged | RMgm-4420
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJF6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 54 | 39 | 64 |
| disruptive | 77 | 126 | 73 | 188 |
| missense | 33 | 82 | 58 | 143 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 33 | 114 | 45 | 71 |
| disruptive | 105 | 261 | 138 | 306 |
| missense | 44 | 191 | 98 | 180 |
PlasmoDB Total SNPs: 570
Non-coding: 352 | Synonymous: 129 | Nonsynonymous: 89 | Stop Codon: 0
Protein Length: 1464 | Molecular Weight (kDa): 171.115
UniProt ID(s): Q8IJF6
PDB ID(s): None
Isoelectric Point: 4.09
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21498641 | Protein targeting to the parasitophorous vacuole membrane of Plasmodiumfalciparum. | Eksi S, Williamson KC | 10.1128/EC.00008-11 |
| 28691708 | An exported protein-interacting complex involved in the trafficking of virulencedeterminants in Plasmodium-infected erythrocytes. | Batinovic S, McHugh E, ..., Tilley L | 10.1038/ncomms16044 |
| 28784333 | Identification of novel parasitophorous vacuole proteins in P. falciparumparasites using BioID. | Khosh-Naucke M, Becker J, ..., Spielmann T | 10.1016/j.ijmm.2017.07.007 |
| 29404413 | Bio ID Reveals Novel Proteins of the Plasmodium Parasitophorous Vacuole Membrane | Schnider CB, Bausch-Fluck D, ..., Burda PC | 10.1128/mSphere.00522-17 |