PF3D7_1024900

Genome location: Pf3D7_10_v3:1,039,937..1,045,239(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	expressed	0.74	0.60
Schizont	possibly expressed	0.17	0.89
Gametocyte	not expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1024900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.18 | MFS: -2.735 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJF5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532449

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	44	29	69
disruptive	149	204	100	237
missense	55	145	81	163

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	97	52	80
disruptive	198	372	179	335
missense	87	246	131	220

PlasmoDB Total SNPs: 367

Non-coding: 63 | Synonymous: 167 | Nonsynonymous: 137 | Stop Codon: 0

Protein Information

Protein Length: 1571 | Molecular Weight (kDa): 190.4

UniProt ID(s): Q8IJF5

PDB ID(s): None

Isoelectric Point: 8.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A