Genome location: Pf3D7_10_v3:1,045,271..1,051,309(-)
Genome classification: Core
Product Description: Eps15-like protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Process | GO:0006897 | endocytosis |
| Process | GO:0016197 | endosomal transport |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.77 | 0.64 |
| Trophozoite | expressed | 0.43 | 0.75 |
| Schizont | expressed | 1.46 | 0.39 |
| Gametocyte | expressed | 0.94 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1025000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.297 | MFS: -2.777 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJF4
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=6.61) with 2PML (Global RMSD=20.38)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101578
Most Similar Human Ortholog: M0R1V5
TM-align score: 0.83 | RMSD: 2.24
Seq Identity: 0.29 | Length: 105 / 980
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000085832 | epidermal growth factor receptor pathway substrate 15 |
| ENSG00000127527 | epidermal growth factor receptor pathway substrate 15 like 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 38 | 27 | 52 |
| disruptive | 59 | 128 | 63 | 146 |
| missense | 24 | 80 | 41 | 109 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 27 | 78 | 40 | 63 |
| disruptive | 108 | 255 | 112 | 244 |
| missense | 48 | 162 | 77 | 165 |
PlasmoDB Total SNPs: 507
Non-coding: 344 | Synonymous: 91 | Nonsynonymous: 72 | Stop Codon: 0
Protein Length: 980 | Molecular Weight (kDa): 116.348
UniProt ID(s): Q8IJF4
PDB ID(s): None
Isoelectric Point: 6.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000261 | EH domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| PFam | PF12763 | EH domain |
| Superfamily | SSF47473 | EF-hand domain pair |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31896710 | A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malariaparasites. | Birnbaum J, Scharf S, ..., Spielmann T | 10.1126/science.aax4735 |
| 37766990 | Light-dependent inhibition of clathrin-mediated endocytosis in yeast unveilsconserved functions of the AP2 complex | Prischich D, Camarero N, ..., Gorostiza P | 10.1016/j.isci.2023.107899 |