Genome location: Pf3D7_10_v3:1,055,678..1,057,237(-)
Genome classification: Core
Product Description: ATP synthase mitochondrial F1 complex assembly factor 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.16 | 0.89 |
| Schizont | not expressed | 0.17 | 0.87 |
| Gametocyte | possibly expressed | 0.33 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1025200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -3.229 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3D4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 17 | 8 | 13 |
| disruptive | 16 | 55 | 23 | 49 |
| missense | 5 | 31 | 17 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 28 | 11 | 13 |
| disruptive | 28 | 102 | 39 | 108 |
| missense | 8 | 60 | 30 | 55 |
PlasmoDB Total SNPs: 89
Non-coding: 9 | Synonymous: 47 | Nonsynonymous: 32 | Stop Codon: 1
Protein Length: 428 | Molecular Weight (kDa): 52.279
UniProt ID(s): C6S3D4
PDB ID(s): None
Isoelectric Point: 8.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011419 | ATP12, ATP synthase F1-assembly protein |
| PFam | N/A | N/A |
| Superfamily | SSF160909 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 35150821 | Gene co-expression network analysis reveals the positive impact of endocytosisand mitochondria-related genes over nitrogen metabolism in Saccharomycescerevisiae | Chen Y, Zeng W, ..., Zhou J | 10.1016/j.gene.2022.146267 |
| 9446613 | Mutational studies with Atp12p, a protein required for assembly of themitochondrial F1-ATPase in yeast. Identification of domains important for Atp12pfunction and oligomerization | Wang ZG, Ackerman SH | 10.1074/jbc.273.5.2993 |
| 10744740 | ASC1/RAS2 suppresses the growth defect on glycerol caused by the atp1-2 mutationin the yeast Saccharomyces cerevisiae | Mabuchi T, Ichimura Y, Takeda M, Douglas MG | 10.1074/jbc.275.14.10492 |
| 19933271 | Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomycescerevisiae yeast model | Meulemans A, Seneca S, ..., Ackerman SH | 10.1074/jbc.M109.046920 |
| 1532796 | Characterization of ATP11 and detection of the encoded protein in mitochondria ofSaccharomyces cerevisiae | Ackerman SH, Martin J, Tzagoloff A | https://pubmed.ncbi.nlm.nih.gov/1532796/ |
| 11096112 | Identification of a nuclear gene (FMC1) required for the assembly/stability ofyeast mitochondrial F(1)-ATPase in heat stress conditions | Lefebvre-Legendre L, Vaillier J, ..., di Rago JP | 10.1074/jbc.M009557200 |