About Gene List

PF3D7_1025300

Genome location: Pf3D7_10_v3:1,057,640..1,060,718(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MLLYFVIFIWSFLLCDI

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.23 0.89
Trophozoite not expressed 1.26 0.39
Schizont not expressed 0.37 0.78
Gametocyte possibly expressed 0.61 0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1025300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.037 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0509500)

  • Relative Growth Rate: 0.02 ± 0.06
  • Confidence: 6.98

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJF2

"Best" AlphaFill ligand hit: PE0 (pterine, Local RMSD=0.61) with 6KCK (Global RMSD=18.37)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533568

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 39 20 40
disruptive 33 63 42 104
missense 16 53 35 95

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 67 34 53
disruptive 48 149 73 170
missense 20 114 62 129

PlasmoDB Total SNPs: 83

Non-coding: 35 | Synonymous: 23 | Nonsynonymous: 23 | Stop Codon: 2

Protein Information

Protein Length: 922 | Molecular Weight (kDa): 109.073

UniProt ID(s): Q8IJF2

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895