PF3D7_1025500

Genome location: Pf3D7_10_v3:1,067,652..1,086,992(-)

Genome classification: Core

Function and Localization

Product Description: dynein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.14	0.94
Trophozoite	not expressed	0.69	0.64
Schizont	not expressed	0.46	0.73
Gametocyte	not expressed	1.51	0.38

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1025500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.819 | #Insertions: 22

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0509700)

Relative Growth Rate: 0.10 ± 0.05
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171383

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	65	252	139	320
disruptive	290	716	424	1003
missense	155	540	370	849

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	108	458	224	370
disruptive	486	1468	727	1399
missense	243	1119	591	1052

PlasmoDB Total SNPs: 896

Non-coding: 306 | Synonymous: 304 | Nonsynonymous: 286 | Stop Codon: 0

Protein Information

Protein Length: 5767 | Molecular Weight (kDa): 695.85

UniProt ID(s): Q8IJE8

PDB ID(s): None

Isoelectric Point: 8.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR040163	RP1/RP1L1/DCX
InterPro	IPR041228	Dynein heavy chain, C-terminal domain
PFam	PF18199	Dynein heavy chain, C-terminal domain
Superfamily	SSF69349	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
19435743	ESG: extended similarity group method for automated protein function prediction.	Chitale M, Hawkins T, Park C, Kihara D	10.1093/bioinformatics/btp309