Genome location: Pf3D7_10_v3:1,087,985..1,088,417(+)
Genome classification: Core
Product Description: cytochrome c oxidase copper chaperone, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0016531 | copper chaperone activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.10 | 0.93 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | not expressed | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1025600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.373 | MFS: -3.608 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0509800)
Modification: Other | RMgm-461
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJE6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103593
Most Similar Human Ortholog: Q14061
TM-align score: 0.62 | RMSD: 2.63
Seq Identity: 0.44 | Length: 48 / 67
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000138495 | cytochrome c oxidase copper chaperone COX17 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 2 | 2 | 2 |
| disruptive | 1 | 3 | 2 | 6 |
| missense | 1 | 2 | 1 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 5 | 3 | 7 |
| disruptive | 3 | 8 | 6 | 10 |
| missense | 1 | 5 | 6 | 8 |
PlasmoDB Total SNPs: 10
Non-coding: 8 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 67 | Molecular Weight (kDa): 7.688
UniProt ID(s): Q8IJE6
PDB ID(s): None
Isoelectric Point: 8.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007745 | Cytochrome c oxidase copper chaperone |
| InterPro | IPR009069 | Cysteine alpha-hairpin motif superfamily |
| PFam | PF05051 | Cytochrome c oxidase copper chaperone |
| Superfamily | SSF47072 | Cysteine alpha-hairpin motif superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 37944620 | Discovery of an unusual copper homeostatic mechanism in yeast cells respiring onminimal medium and an unexpectedly diverse labile copper pool | Kim JE, Jeon S, Lindahl PA | 10.1016/j.jbc.2023.105435 |
| 37990816 | MKT1 alleles regulate stress responses through posttranscriptional modulation ofPuf3 targets in budding yeast | Chaithanya KV, Sinha H | 10.1002/yea.3908 |