PF3D7_1025700

Genome location: Pf3D7_10_v3:1,088,931..1,089,909(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.50	0.70
Schizont	expressed	0.11	0.92
Gametocyte	expressed	0.39	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1025700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.361 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJE5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146179

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	3	2
disruptive	2	11	11	23
missense	2	11	11	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	11	4	9
disruptive	4	29	28	50
missense	2	26	24	34

PlasmoDB Total SNPs: 52

Non-coding: 43 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 187 | Molecular Weight (kDa): 23.132

UniProt ID(s): Q8IJE5

PDB ID(s): None

Isoelectric Point: 11.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A