About Gene List

PF3D7_1025900

Genome location: Pf3D7_10_v3:1,090,935..1,098,006(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.14 0.93
Trophozoite expressed 0.53 0.74
Schizont expressed 2.16 0.24
Gametocyte expressed 1.11 0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1025900

Resistome Missense Mutations: N998K

Resistome Compounds with Missense Mutations: MMV1432711

Resistome # Samples with Disruptive Mutations: 10 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.237 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZYA5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532658

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 60 32 92
disruptive 53 167 108 204
missense 40 140 98 192

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 116 58 96
disruptive 88 346 145 292
missense 51 289 133 231

PlasmoDB Total SNPs: 509

Non-coding: 393 | Synonymous: 71 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 1331 | Molecular Weight (kDa): 156.663

UniProt ID(s): A0A143ZYA5

PDB ID(s): None

Isoelectric Point: 7.36

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
29269729 A conserved ankyrin repeat-containing protein regulates conoid stability,motility and cell invasion in Toxoplasma gondii. Long S, Anthony B, Drewry LL, Sibley LD 10.1038/s41467-017-02341-2