About Gene List

PF3D7_1026000

Genome location: Pf3D7_10_v3:1,098,008..1,100,175(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.49 0.77
Trophozoite expressed 1.08 0.46
Schizont expressed 0.35 0.78
Gametocyte expressed 0.91 0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1026000

Resistome Missense Mutations: E241K

Resistome Compounds with Missense Mutations: Halofuginone

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.464 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJE1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532318

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 11 8 10
disruptive 43 92 36 85
missense 15 42 17 47

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 25 7 15
disruptive 84 159 54 105
missense 26 82 30 62

PlasmoDB Total SNPs: 210

Non-coding: 144 | Synonymous: 29 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 363 | Molecular Weight (kDa): 43.154

UniProt ID(s): Q8IJE1

PDB ID(s): None

Isoelectric Point: 9.15

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108