PF3D7_1026100

Genome location: Pf3D7_10_v3:1,101,024..1,103,427(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.10	0.94
Schizont	not expressed	0.03	0.98
Gametocyte	expressed	1.22	0.44

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1026100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.991 | MFS: -2.559 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJE0

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.14) with 3A4L (Global RMSD=23.28)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532445

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	2	9	11
disruptive	2	15	10	24
missense	2	14	8	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	14	9	13
disruptive	6	42	24	49
missense	5	29	17	29

PlasmoDB Total SNPs: 149

Non-coding: 135 | Synonymous: 11 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 194 | Molecular Weight (kDa): 23.872

UniProt ID(s): Q8IJE0

PDB ID(s): None

Isoelectric Point: 8.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A