About Gene List

PF3D7_1026300

Genome location: Pf3D7_10_v3:1,105,482..1,109,722(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite expressed 0.43 0.75
Schizont possibly expressed 0.07 0.96
Gametocyte expressed 0.67 0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1026300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: -2.721 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0510500)

  • Relative Growth Rate: 0.90 ± 0.20
  • Confidence: 4.64

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0510500)

Modification: Disrupted | RMgm-1979

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJD8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533675

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 41 34 70
disruptive 49 162 89 194
missense 22 125 73 165

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 90 60 78
disruptive 86 332 149 262
missense 41 256 122 196

PlasmoDB Total SNPs: 330

Non-coding: 188 | Synonymous: 93 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 1121 | Molecular Weight (kDa): 134.938

UniProt ID(s): Q8IJD8

PDB ID(s): None

Isoelectric Point: 6.79

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104