Genome location: Pf3D7_10_v3:1,109,794..1,111,976(-)
Genome classification: Core
Product Description: cell division cycle protein 20 homolog, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005680 | anaphase-promoting complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0010997 | anaphase-promoting complex binding |
| Function | GO:1990757 | ubiquitin ligase activator activity |
| Process | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| Process | GO:1905786 | positive regulation of anaphase-promoting complex-dependent catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | not expressed | 0.07 | 0.96 |
| Schizont | not expressed | 0.07 | 0.96 |
| Gametocyte | not expressed | 0.58 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1026400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.469 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0510600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0510600)
Modification: Disrupted | RMgm-1980
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJD7
"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.83) with 6Y7O (Global RMSD=4.14)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101383
Most Similar Human Ortholog: Q9UM11
TM-align score: 0.66 | RMSD: 2.21
Seq Identity: 0.39 | Length: 340 / 603
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105325 | fizzy and cell division cycle 20 related 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 23 | 12 | 30 |
| disruptive | 4 | 46 | 37 | 94 |
| missense | 4 | 45 | 36 | 92 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 42 | 28 | 35 |
| disruptive | 17 | 113 | 64 | 136 |
| missense | 12 | 103 | 59 | 114 |
PlasmoDB Total SNPs: 63
Non-coding: 28 | Synonymous: 23 | Nonsynonymous: 12 | Stop Codon: 0
Protein Length: 603 | Molecular Weight (kDa): 71.631
UniProt ID(s): Q8IJD7
PDB ID(s): None
Isoelectric Point: 9.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR020472 | G-protein beta WD-40 repeat |
| InterPro | IPR024977 | Anaphase-promoting complex subunit 4, WD40 domain |
| InterPro | IPR033010 | The WD repeat Cdc20/Fizzy family |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| PFam | PF12894 | Anaphase-promoting complex subunit 4, WD40 domain |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 22383885 | A putative homologue of CDC20/CDH1 in the malaria parasite is essential for malegamete development. | Guttery DS, Ferguson DJ, ..., Tewari R | 10.1371/journal.ppat.1002554 |