About Gene List

PF3D7_1026600

Genome location: Pf3D7_10_v3:1,113,232..1,119,224(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 2.42 0.31
Trophozoite not expressed 0.71 0.66
Schizont expressed 1.28 0.55
Gametocyte expressed 0.77 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1026600

Resistome Missense Mutations: M295I

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.348 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJD6

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=19.75) with 6JWQ (Global RMSD=34.70)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130061

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 15 65 51 99
disruptive 81 267 144 335
missense 48 231 121 287

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 138 70 107
disruptive 137 528 228 434
missense 81 434 189 330

PlasmoDB Total SNPs: 397

Non-coding: 127 | Synonymous: 138 | Nonsynonymous: 129 | Stop Codon: 3

Protein Information

Protein Length: 1692 | Molecular Weight (kDa): 196.492

UniProt ID(s): Q8IJD6

PDB ID(s): None

Isoelectric Point: 9.9

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108