Genome location: Pf3D7_10_v3:1,121,930..1,124,959(+)
Genome classification: Core
Product Description: 40S ribosomal protein S2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0002181 | cytoplasmic translation |
| Process | GO:0000028 | ribosomal small subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.17 | 0.50 |
| Trophozoite | expressed | 1.42 | 0.35 |
| Schizont | expressed | 0.20 | 0.88 |
| Gametocyte | expressed | 0.59 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1026800
Resistome Missense Mutations: L214I
Resistome Compounds with Missense Mutations: Suloctidil
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.592 | MFS: -2.415 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0510900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJD4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100806
Most Similar Human Ortholog: F8WD59
TM-align score: 0.90 | RMSD: 1.00
Seq Identity: 0.57 | Length: 108 / 263
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000168028 | ribosomal protein SA |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 183
Non-coding: 177 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 263 | Molecular Weight (kDa): 29.856
UniProt ID(s): A0A143ZZG2, Q8IJD4
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP, 6OKK
Isoelectric Point: 6.14
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001865 | Ribosomal protein S2 |
| InterPro | IPR005707 | Ribosomal protein S2, eukaryotic/archaeal |
| InterPro | IPR018130 | Ribosomal protein S2, conserved site |
| InterPro | IPR023591 | Ribosomal protein S2, flavodoxin-like domain superfamily |
| InterPro | IPR027498 | Ribosomal protein S2, eukaryotic |
| PFam | PF00318 | Ribosomal protein S2 |
| Superfamily | SSF52313 | Ribosomal protein S2, flavodoxin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 37751644 | Screening of genes encoding proteins that interact with Nrf2: Probing a cDNAlibrary from Mytilus coruscus using a yeast two-hybrid system | Zhu L, Li Y, ..., Qi P | 10.1016/j.fsi.2023.109112 |