PF3D7_1027000

Genome location: Pf3D7_10_v3:1,126,277..1,132,406(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.10	0.95
Trophozoite	possibly expressed	0.24	0.86
Schizont	expressed	0.07	0.96
Gametocyte	expressed	0.72	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1027000

Resistome Missense Mutations: D126E

Resistome Compounds with Missense Mutations: TCMDC-124553/MMV019869

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.655 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0511100)

Modification: Other | RMgm-475

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJD3

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.07) with 2BVL (Global RMSD=27.29)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532364

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	82	54	104
disruptive	116	303	153	331
missense	40	202	126	246

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	44	158	70	127
disruptive	221	553	229	484
missense	92	383	160	337

PlasmoDB Total SNPs: 437

Non-coding: 80 | Synonymous: 224 | Nonsynonymous: 133 | Stop Codon: 0

Protein Information

Protein Length: 1811 | Molecular Weight (kDa): 216.655

UniProt ID(s): Q8IJD3

PDB ID(s): None

Isoelectric Point: 5.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A