Genome location: Pf3D7_10_v3:1,133,359..1,136,667(-)
Genome classification: Core
Product Description: U3 small nucleolar ribonucleoprotein protein MPP10, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034457 | Mpp10 complex |
| Component | GO:0032040 | small-subunit processome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.34 | 0.45 |
| Trophozoite | expressed | 0.81 | 0.59 |
| Schizont | expressed | 0.24 | 0.87 |
| Gametocyte | expressed | 0.72 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1027100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.779 | #Insertions: 2
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0511200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJD2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102269
Most Similar Human Ortholog: O00566
TM-align score: 0.38 | RMSD: 5.19
Seq Identity: 0.22 | Length: 312 / 772
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000124383 | M-phase phosphoprotein 10 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 39 | 10 | 30 |
| disruptive | 65 | 156 | 62 | 155 |
| missense | 23 | 80 | 42 | 110 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 58 | 19 | 45 |
| disruptive | 119 | 257 | 104 | 198 |
| missense | 44 | 151 | 77 | 118 |
PlasmoDB Total SNPs: 266
Non-coding: 91 | Synonymous: 73 | Nonsynonymous: 100 | Stop Codon: 2
Protein Length: 772 | Molecular Weight (kDa): 92.467
UniProt ID(s): Q8IJD2
PDB ID(s): None
Isoelectric Point: 4.24
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR012173 | U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 |
| PFam | PF04006 | U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21890904 | A second base pair interaction between U3 small nucleolar RNA and the 5'-ETSregion is required for early cleavage of the yeast pre-ribosomal RNA | Marmier-Gourrier N, Clery A, ..., Branlant C | 10.1093/nar/gkr675 |
| 32524281 | Anti-infective nitazoxanide disrupts transcription of ribosome biogenesis-relatedgenes in yeast | Xu S, Yamamoto N | 10.1007/s13258-020-00958-0 |
| 25005089 | Purification, crystallization and preliminary X-ray diffraction analysis of Imp3in complex with an Mpp10 peptide involved in yeast ribosome biogenesis | Zheng S, Ye K | 10.1107/S2053230X14010905 |
| 21115740 | Adjacent gene pairing plays a role in the coordinated expression of ribosomebiogenesis genes MPP10 and YJR003C in Saccharomyces cerevisiae | Arnone JT, McAlear MA | 10.1128/EC.00257-10 |
| 24706020 | Dissecting the cis and trans elements that regulate adjacent-gene coregulation inSaccharomyces cerevisiae | Arnone JT, Arace JR, ..., McAlear MA | 10.1128/EC.00317-13 |