Genome location: Pf3D7_10_v3:1,136,887..1,140,020(+)
Genome classification: Core
Product Description: ribosomal protein RSM22
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Process | GO:0032543 | mitochondrial translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.19 | 0.88 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.12 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1027200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.995 | MFS: -2.07 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0511300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJD1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103043
Most Similar Human Ortholog: Q9H7H0
TM-align score: 0.72 | RMSD: 3.24
Seq Identity: 0.22 | Length: 361 / 520
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000165792 | methyltransferase like 17 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 42 | 8 | 37 |
| disruptive | 2 | 33 | 17 | 72 |
| missense | 2 | 30 | 14 | 58 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 61 | 17 | 33 |
| disruptive | 8 | 71 | 41 | 132 |
| missense | 4 | 54 | 36 | 98 |
PlasmoDB Total SNPs: 129
Non-coding: 97 | Synonymous: 24 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 520 | Molecular Weight (kDa): 61.468
UniProt ID(s): Q8IJD1
PDB ID(s): None
Isoelectric Point: 10.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR015324 | Ribosomal protein Rsm22-like |
| InterPro | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase |
| PFam | PF09243 | Ribosomal protein Rsm22-like |
| Superfamily | SSF53335 | S-adenosyl-L-methionine-dependent methyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 25803831 | ATG18 and FAB1 are involved in dehydration stress tolerance in Saccharomycescerevisiae | Lopez-Martinez G, Margalef-Catala M, ..., Cordero-Otero R | 10.1371/journal.pone.0119606 |
| 34076597 | Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 fromSaccharomyces cerevisiae | Alam J, Rahman FT, ..., Kastaniotis AJ | 10.1107/S2059798321004149 |
| 16835444 | Sequential processing of a mitochondrial tandem protein: insights into proteinimport in Schizosaccharomyces pombe | Khalimonchuk O, Ott M, ..., Herrmann JM | 10.1128/EC.00092-06 |
| 36201550 | Transcriptional changes in Plasmodium falciparum upon conditional knock down ofmitochondrial ribosomal proteins RSM22 and L23 | Dass S, Mather MW, ..., Ke H | 10.1371/journal.pone.0274993 |
| 28089944 | RSM22, mtYsxC and PNKD-like proteins are required for mitochondrial translationin Trypanosoma brucei | Tyc J, Novotna L, ..., Lukes J | 10.1016/j.mito.2017.01.003 |