Genome location: Pf3D7_10_v3:1,139,669..1,144,013(-)
Genome classification: Core
Product Description: peroxiredoxin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.11.1.15 (Transferred entry: 1.11.1.24)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0008379 | thioredoxin peroxidase activity |
| Process | GO:0045454 | cell redox homeostasis |
| Process | GO:0034599 | cellular response to oxidative stress |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.35 | 0.18 |
| Trophozoite | expressed | 1.85 | 0.30 |
| Schizont | expressed | 3.58 | 0.07 |
| Gametocyte | expressed | 1.28 | 0.41 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1027300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.68 | MFS: -2.377 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0511400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0511400)
Modification: Disrupted | RMgm-1986
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJD0
"Best" AlphaFill ligand hit: FL0 (2-bromanyl-1-phenyl-ethanone, Local RMSD=0.13) with 7C89 (Global RMSD=1.56)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.11.1.15 | peroxiredoxin | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 305
Non-coding: 257 | Synonymous: 31 | Nonsynonymous: 16 | Stop Codon: 1
Protein Length: 393 | Molecular Weight (kDa): 43.93
UniProt ID(s): O76465, Q25710, Q8IJD0, Q9TZS2
PDB ID(s): None
Isoelectric Point: 10.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000866 | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF00578 | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18832006 | Identification of peptides with high red blood cell and hepatocyte bindingactivity in the Plasmodium falciparum multi-stage invasion proteins: PfSPATR andMCP-1. | Curtidor H, Garcia J, ..., Patarroyo ME | 10.1016/j.biochi.2008.08.003 |
| 21282103 | A genome-wide chromatin-associated nuclear peroxiredoxin from the malariaparasite Plasmodium falciparum. | Richard D, Bartfai R, ..., Cowman AF | 10.1074/jbc.M110.198499 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |