Genome location: Pf3D7_10_v3:1,150,507..1,152,207(-)
Genome classification: Core
Product Description: centrin-3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005813 | centrosome |
| Component | GO:0005815 | microtubule organizing center |
| Component | GO:0031965 | nuclear membrane |
| Component | GO:0005634 | nucleus |
| Function | GO:0005509 | calcium ion binding |
| Function | GO:0008017 | microtubule binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1027700.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.888 | MFS: -2.345 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZXT2
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.39) with 8FNY (Global RMSD=1.54)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104526
Most Similar Human Ortholog: O15182
TM-align score: 0.78 | RMSD: 2.57
Seq Identity: 0.58 | Length: 156 / 179
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000153140 | centrin 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 7 | 4 | 14 |
| disruptive | 0 | 1 | 3 | 8 |
| missense | 0 | 1 | 3 | 6 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 12 | 10 | 15 |
| disruptive | 1 | 9 | 6 | 22 |
| missense | 0 | 5 | 5 | 17 |
PlasmoDB Total SNPs: 107
Non-coding: 102 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 179 | Molecular Weight (kDa): 20.913
UniProt ID(s): Q8IJC7
PDB ID(s): None
Isoelectric Point: 4.54
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002048 | EF-hand domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| PFam | PF13499 | EF-hand domain |
| Superfamily | SSF47473 | EF-hand domain pair |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 11124900 | Only centromeres can supply the partition system required for ARS function in theyeast Yarrowia lipolytica | Vernis L, Poljak L, ..., Fournier P | 10.1006/jmbi.2000.4300 |
| 11063678 | CSE4 genetically interacts with the Saccharomyces cerevisiae centromere DNAelements CDE I and CDE II but not CDE III. Implications for the path of thecentromere dna around a cse4p variant nucleosome | Keith KC, Fitzgerald-Hayes M | 10.1093/genetics/156.3.973 |