Genome location: Pf3D7_10_v3:1,153,081..1,155,488(-)
Genome classification: Core
Product Description: 60S ribosomal protein L3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005622 | intracellular |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000027 | ribosomal large subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.64 | 0.35 |
| Trophozoite | expressed | 2.11 | 0.18 |
| Schizont | expressed | 0.43 | 0.75 |
| Gametocyte | expressed | 1.00 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1027800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.144 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_0513000)
Modification: Tagged | RMgm-1567
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJC6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
Ortholog Group (OrthoMCL): OG6_100665
Most Similar Human Ortholog: P39023
TM-align score: 0.99 | RMSD: 0.63
Seq Identity: 0.65 | Length: 386 / 386
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100316 | ribosomal protein L3 |
| ENSG00000140986 | ribosomal protein L3 like |
Protein Length: 386 | Molecular Weight (kDa): 44.221
UniProt ID(s): Q8IJC6
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000597 | Ribosomal protein L3 |
| InterPro | IPR009000 | Translation protein, beta-barrel domain superfamily |
| InterPro | IPR019926 | Ribosomal protein L3, conserved site |
| PFam | PF00297 | Ribosomal protein L3 |
| Superfamily | SSF50447 | Translation protein, beta-barrel domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 19 | 9 | 24 |
| disruptive | 0 | 2 | 2 | 16 |
| missense | 0 | 2 | 2 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 44 | 12 | 20 |
| disruptive | 1 | 9 | 15 | 41 |
| missense | 1 | 5 | 11 | 28 |
PlasmoDB Total SNPs: 120
Non-coding: 111 | Synonymous: 8 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 27503796 | Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. | Siau A, Huang X, ..., Preiser PR | 10.1038/srep31055 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 36882085 | Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart | Milenkovic I, Santos Vieira HG, ..., Novoa EM | 10.1093/nar/gkad121 |